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Thus, smoking is associated with specific structural alterations to the lipid-A-derived 3-OH fatty acid profile in saliva that are consistent with an oral microflora of reduced inflammatory potential.(6)

Since there's not enough data over a long period, you can't be sure if using these pouches, even if they expose you to less nicotine, is safer

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In a study investigating the role of innovative packaging, the authors wrote: Jugger (1999) argues that the best way to obtain competitive advantage in an overloaded consumer goods market is through innovation in packaging